Reduced Fractalkine Levels Lead to Striatal Synaptic Plasticity Deficits in Huntington’s Disease

Reduced Fractalkine Levels Lead to Striatal Synaptic Plasticity Deficits in Huntington’s Disease

Huntington’s disease (HD) is an inherited neurodegenerative disorder in which the striatum is the most affected brain region. Although a chronic inflammatory microglial reaction that amplifies disease progression has been described in HD patients, some murine models develop symptoms without inflamma...

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Bibliographic Details
Main Authors: Anya Kim, Esther García-García, Marco Straccia, Andrea Comella-Bolla, Andrés Miguez, Mercè Masana, Jordi Alberch, Josep M. Canals, Manuel J. Rodríguez
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
huntingtin
CX3CL1
microglia
corticostriatal pathway
synaptic pruning
human iPSC
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00163/full

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https://www.frontiersin.org/article/10.3389/fncel.2020.00163/full

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