Intratumoral CD38+CD19+B cells associate with poor clinical outcomes and immunosuppression in patients with pancreatic ductal adenocarcinomaResearch in context

Intratumoral CD38+CD19+B cells associate with poor clinical outcomes and immunosuppression in patients with pancreatic ductal adenocarcinomaResearch in context

Summary: Background: The widespread involvement of tumor-infiltrating B cells highlights their potential role in tumor behavior. However, B cell heterogeneity in PDAC remains unexplored. Studying TIL-Bs in PDAC aims to identify new treatment strategies. Methods: We performed single-cell RNA sequenc...

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Bibliographic Details
Main Authors: Heng Zhu, Jin Xu, Wei Wang, Bo Zhang, Jiang Liu, Chen Liang, Jie Hua, Qingcai Meng, Xianjun Yu, Si Shi
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:EBioMedicine
Subjects:
CD38+CD19+ B cell
Pancreatic ductal adenocarcinoma
Immunosuppression
Clinical outcome
Immunotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396424001336

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http://www.sciencedirect.com/science/article/pii/S2352396424001336

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