Simvastatin induces pyroptosis via ROS/caspase-1/GSDMD pathway in colon cancer

Simvastatin induces pyroptosis via ROS/caspase-1/GSDMD pathway in colon cancer

Abstract Background The outcome of patients with colon cancer is still unsatisfied nowadays. Simvastatin is a type of statins with anti-cancer activity, but its effect on colon cancer cells remains unclear. The present study is intended to determine the underlying mechanism of simvastatin in treatme...

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Bibliographic Details
Main Authors: Wei Xie, Mingjing Peng, Ying Liu, Bocheng Zhang, Liang Yi, Ying Long
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Cell Communication and Signaling
Subjects:
Simvastatin
Caspase-1
Pyroptosis
ROS
Colon cancer
Online Access:https://doi.org/10.1186/s12964-023-01359-y

Internet

https://doi.org/10.1186/s12964-023-01359-y

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