A shared transcriptional code orchestrates temporal patterning of the central nervous system.

The molecular mechanisms that produce the full array of neuronal subtypes in the vertebrate nervous system are incompletely understood. Here, we provide evidence of a global temporal patterning program comprising sets of transcription factors that stratifies neurons based on the developmental time a...

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Bibliographic Details
Main Authors: Andreas Sagner, Isabel Zhang, Thomas Watson, Jorge Lazaro, Manuela Melchionda, James Briscoe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-11-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3001450