Prognostic value of functional SMAD4 localization in extrahepatic bile duct cancer

Prognostic value of functional SMAD4 localization in extrahepatic bile duct cancer

Abstract Background SMAD4 is a key mediator of TGFβ signaling and one of the mutated genes in extrahepatic bile duct cancer (eBDC). It has been also reported that SMAD4 has dual functions, in carcinogenesis via silencing and in tumor invasion/metastasis via signaling, depending on tumor stage. We pr...

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Bibliographic Details
Main Authors: Hirotoshi Takayama, Shogo Kobayashi, Kunihito Gotoh, Kazuki Sasaki, Yoshifumi Iwagami, Daisaku Yamada, Yoshito Tomimaru, Hirofumi Akita, Tadafumi Asaoka, Takehiro Noda, Hiroshi Wada, Hidenori Takahashi, Masahiro Tanemura, Yuichiro Doki, Hidetoshi Eguchi
Format: Article
Language:English
Published: BMC 2022-09-01
Series:World Journal of Surgical Oncology
Subjects:
Extrahepatic biliary bile duct cancer
SMAD4
Intra-tumoral localization
Chemoradiation therapy
Online Access:https://doi.org/10.1186/s12957-022-02747-3

Internet

https://doi.org/10.1186/s12957-022-02747-3

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