Evaluation of the Association between Single Nucleotide Polymorphisms of Metabolizing Enzymes with the Serum Concentration of Paracetamol and Its Metabolites

Evaluation of the Association between Single Nucleotide Polymorphisms of Metabolizing Enzymes with the Serum Concentration of Paracetamol and Its Metabolites

Intravenous paracetamol is a commonly administered analgesic and antipyretic in inpatient settings. Paracetamol is metabolized by cytochrome P450 (CYP) enzymes followed by conjugating enzymes to mainly glucuronide but to a lesser extent, sulphate metabolites, and oxidative metabolites. Single nucleo...

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Bibliographic Details
Main Authors: Kannan Sridharan, Ali Mohamed Qader, Mustafa Hammad, Anfal Jassim, Diab Eltayeb Diab, Betsy Abraham, Hasan M. S. N. Hasan, Sheikh Abdul Azeez Pasha, Shamik Shah
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Metabolites
Subjects:
paracetamol
acetaminophen
paracetamol sulphate
paracetamol glucuronide
pharmacogenetics
Online Access:https://www.mdpi.com/2218-1989/12/12/1235

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