Targeting microglial NLRP3 in the SNc region as a promising disease‐modifying therapy for Parkinson's disease

Targeting microglial NLRP3 in the SNc region as a promising disease‐modifying therapy for Parkinson's disease

Abstract Introduction Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive loss of dopaminergic (DA) neurons. Accumulating evidence has shown that activation of the NLR family pyrin domain‐containing 3 (NLRP3) inflammasome is an early and cardinal feature in PD...

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Bibliographic Details
Main Authors: Chen Qiao, Tao Dang, Yan Zhou, Yuan‐Zhang Zhou, Rong Zhao, Min Wang
Format: Article
Language:English
Published: Wiley 2022-11-01
Series:Brain and Behavior
Subjects:
disease‐modifying therapy
dopaminergic neuron
microglia
NLRP3
Parkinson's disease
Online Access:https://doi.org/10.1002/brb3.2784

Internet

https://doi.org/10.1002/brb3.2784

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