Pyrrolidine Dithiocarbamate (PDTC) Attenuates Cancer Cachexia by Affecting Muscle Atrophy and Fat Lipolysis

Pyrrolidine Dithiocarbamate (PDTC) Attenuates Cancer Cachexia by Affecting Muscle Atrophy and Fat Lipolysis

Cancer cachexia is a kind of whole body metabolic disorder syndrome accompanied with severe wasting of muscle and adipose tissue. NF-κB signaling plays an important role during skeletal muscle atrophy and fat lipolysis. As an inhibitor of NF-κB signaling, Pyrrolidine dithiocarbamate (PDTC) was repor...

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Bibliographic Details
Main Authors: Chunxiao Miao, Yuanyuan Lv, Wanli Zhang, Xiaoping Chai, Lixing Feng, Yanfen Fang, Xuan Liu, Xiongwen Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Pharmacology
Subjects:
cancer cachexia
PDTC
C2C12 myotubes
3T3-L1 adipocytes
muscle atrophy
fat lipolysis
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00915/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00915/full

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