Orally Administered, Biodegradable and Biocompatible Hydroxypropyl–β–Cyclodextrin Grafted Poly(methacrylic acid) Hydrogel for pH Sensitive Sustained Anticancer Drug Delivery

Orally Administered, Biodegradable and Biocompatible Hydroxypropyl–β–Cyclodextrin Grafted Poly(methacrylic acid) Hydrogel for pH Sensitive Sustained Anticancer Drug Delivery

In the current study, a pH sensitive intelligent hydroxypropyl–β–cyclodextrin-based polymeric network (HP-β-CD-g-MAA) was developed through a solution polymerization technique for site specific delivery of cytarabine in the colonic region. Prepared hydrogel formulations were characterized through cy...

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Bibliographic Details
Main Authors: Nighat Batool, Rai Muhammad Sarfraz, Asif Mahmood, Muhammad Zaman, Nadiah Zafar, Ahmad Salawi, Yosif Almoshari, Meshal Alshamrani
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Gels
Subjects:
cytarabine
hydroxypropyl–β–cyclodextrin
pharmacokinetics
half-life
colorectal cancer
Online Access:https://www.mdpi.com/2310-2861/8/3/190

Internet

https://www.mdpi.com/2310-2861/8/3/190

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