Copy number alteration features in pan-cancer homologous recombination deficiency prediction and biology

Copy number alteration features in pan-cancer homologous recombination deficiency prediction and biology

Abstract Homologous recombination deficiency (HRD) renders cancer cells vulnerable to unrepaired double-strand breaks and is an important therapeutic target as exemplified by the clinical efficacy of poly ADP-ribose polymerase (PARP) inhibitors as well as the platinum chemotherapy drugs applied to H...

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Bibliographic Details
Main Authors: Huizi Yao, Huimin Li, Jinyu Wang, Tao Wu, Wei Ning, Kaixuan Diao, Chenxu Wu, Guangshuai Wang, Ziyu Tao, Xiangyu Zhao, Jing Chen, Xiaoqin Sun, Xue-Song Liu
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-04901-3

Internet

https://doi.org/10.1038/s42003-023-04901-3

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