Development of chimeric antigen receptor (CAR)-T cells targeting A56 viral protein implanted by oncolytic virus

Development of chimeric antigen receptor (CAR)-T cells targeting A56 viral protein implanted by oncolytic virus

Summary: To address the challenge of solid tumor targeting in CAR-T therapy, we utilized the A56 antigen, which is uniquely expressed on a diverse range of cancer cells following the systemic administration of an oncolytic vaccinia virus (OVV). Immunohistochemical assays precisely confirmed exclusiv...

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Bibliographic Details
Main Authors: Euna Cho, Min Ho An, Yi Sle Lee, Eun Jin Ryu, You Ra Lee, So Youn Park, Ye Ji Kim, Chan Hee Lee, Dayoung Oh, Min Seo Kim, Nam Deuk Kim, Jae-Joon Kim, Young Mi Hong, Mong Cho, Tae Ho Hwang
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:iScience
Subjects:
Immunology
Cell biology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224004772

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http://www.sciencedirect.com/science/article/pii/S2589004224004772

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