Histone Deacetylase 6 Inhibitor CKD-WID Suppressed Monosodium Urate-Induced Osteoclast Formation by Blocking Calcineurin-NFAT Pathway in RAW 264.7 Cells

Histone Deacetylase 6 Inhibitor CKD-WID Suppressed Monosodium Urate-Induced Osteoclast Formation by Blocking Calcineurin-NFAT Pathway in RAW 264.7 Cells

Histone deacetylase (HDAC) has been found to play a crucial role in the regulation of osteoclast differentiation and formation. This study was designed to identify the effect of the HDAC6 inhibitor CKD-WID on the receptor for the activation of nuclear factor-κB ligand (RANKL)-mediated osteoclast for...

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Bibliographic Details
Main Authors: Seong-Kyu Kim, Jung-Yoon Choe, Ji-Won Kim, Ki-Yeun Park
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Pharmaceuticals
Subjects:
histone deacetylase
CKD-WID
osteoclast
monosodium urate
calcineurin
Online Access:https://www.mdpi.com/1424-8247/16/3/446

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https://www.mdpi.com/1424-8247/16/3/446

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