Cavin‐2 promotes fibroblast‐to‐myofibroblast trans‐differentiation and aggravates cardiac fibrosis

Cavin‐2 promotes fibroblast‐to‐myofibroblast trans‐differentiation and aggravates cardiac fibrosis

Abstract Aims Transforming growth factor β (TGF‐β) signalling is one of the critical pathways in fibroblast activation, and several drugs targeting the TGF‐β/Smad signalling pathway in heart failure with cardiac fibrosis are being tested in clinical trials. Some caveolins and cavins, which are compo...

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Bibliographic Details
Main Authors: Yusuke Higuchi, Takehiro Ogata, Naohiko Nakanishi, Masahiro Nishi, Yumika Tsuji, Shinya Tomita, Simon J. Conway, Satoaki Matoba
Format: Article
Language:English
Published: Wiley 2024-02-01
Series:ESC Heart Failure
Subjects:
Cardiac fibrosis
Cavin‐2
Fibroblasts
TGF‐β/Smad signalling
Online Access:https://doi.org/10.1002/ehf2.14571

Internet

https://doi.org/10.1002/ehf2.14571

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