LY354740 Reduces Extracellular Glutamate Concentration, Inhibits Phosphorylation of Fyn/NMDARs, and Expression of PLK2/pS129 α-Synuclein in Mice Treated With Acute or Sub-Acute MPTP

LY354740 Reduces Extracellular Glutamate Concentration, Inhibits Phosphorylation of Fyn/NMDARs, and Expression of PLK2/pS129 α-Synuclein in Mice Treated With Acute or Sub-Acute MPTP

Glutamate overactivity in basal ganglia critically contributes to the exacerbation of dopaminergic neuron degeneration in Parkinson’s disease (PD). Activation of group II metabotropic glutamate receptors (mGlu2/3 receptors), which can decrease excitatory glutamate neurotransmission, provides an oppo...

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Bibliographic Details
Main Authors: Yang Tan, Yan Xu, Chi Cheng, Cong Zheng, Weiqi Zeng, Ji Wang, Xiaoqian Zhang, Xiaoman Yang, Jialing Wang, Xiaomei Yang, Shuke Nie, Xuebing Cao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Pharmacology
Subjects:
Parkinson’s disease
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
metabotropic glutamate receptor
NMDA receptor
Fyn kinase
Polo-like kinase
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00183/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00183/full

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