M1 cholinergic signaling in the brain modulates cytokine levels and splenic cell sub-phenotypes following cecal ligation and puncture

M1 cholinergic signaling in the brain modulates cytokine levels and splenic cell sub-phenotypes following cecal ligation and puncture

Abstract Background The contribution of the central nervous system to sepsis pathobiology is incompletely understood. In previous studies, administration of endotoxin to mice decreased activity of the vagus anti-inflammatory reflex. Treatment with the centrally-acting M1 muscarinic acetylcholine (AC...

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Bibliographic Details
Main Authors: Mabel N. Abraham, Ana Nedeljkovic-Kurepa, Tiago D. Fernandes, Omar Yaipen, Mariana R. Brewer, Daniel E. Leisman, Matthew D. Taylor, Clifford S. Deutschman
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Molecular Medicine
Subjects:
Sepsis
Sepsis-3
Organ dysfunction
Cecal ligation and puncture
Basal forebrain cholinergic system
Muscarinic receptors
Online Access:https://doi.org/10.1186/s10020-024-00787-x

Internet

https://doi.org/10.1186/s10020-024-00787-x

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