Synthesis and In Vitro Anticancer Activity of Novel 4-Aryl-3-(4-methoxyphenyl)-1-phenyl-1<i>H</i>-pyrazolo[3,4-<i>b</i>]pyridines Arrest Cell Cycle and Induce Cell Apoptosis by Inhibiting CDK2 and/or CDK9

Synthesis and In Vitro Anticancer Activity of Novel 4-Aryl-3-(4-methoxyphenyl)-1-phenyl-1<i>H</i>-pyrazolo[3,4-<i>b</i>]pyridines Arrest Cell Cycle and Induce Cell Apoptosis by Inhibiting CDK2 and/or CDK9

Two series of pyrazolo[3,4-<i>b</i>]pyridine derivatives, <b>9a</b>–<b>h</b> and <b>14a</b>–<b>h</b>, are synthesized and evaluated for their anti-cancer potency towards Hela, MCF7, and HCT-116 cancer cell lines. Compound <b>9a</b&...

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Bibliographic Details
Main Authors: Basma S. Almansour, Faizah A. Binjubair, Alaa A.-M. Abdel-Aziz, Sara T. Al-Rashood
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Molecules
Subjects:
pyrazolo[3,4-<i>b</i>]pyridines
anti-cancer
cell cycle
apoptosis
CDK2
CDK9
Online Access:https://www.mdpi.com/1420-3049/28/17/6428

Internet

https://www.mdpi.com/1420-3049/28/17/6428

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