Synthesis and the antidepressant-like activity investigation of bis-(N-monosuccinyl-D-seryl-D-lysine) hexamethylenediamide, the DD-enantiomer of the BDNF dipeptide mimetic, compound GSB-106
Previously, based on the β-turn of the fourth loop of the brain-derived neurotrophic factor, we obtained GSB-106 (bis-(N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide), that has pronounced neuroprotective and antidepressant activities in doses of 0.1–10 mg/kg with intraperitoneal and oral admi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
LLC “Publisher OKI”
2024-11-01
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| Series: | Фармакокинетика и Фармакодинамика |
| Subjects: | |
| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/425 |