LIMD1 Increases the Sensitivity of Lung Adenocarcinoma Cells to Cisplatin via the GADD45α/p38 MAPK Signaling Pathway

LIMD1 Increases the Sensitivity of Lung Adenocarcinoma Cells to Cisplatin via the GADD45α/p38 MAPK Signaling Pathway

Objective: To investigate the effect of LIM domain-containing protein 1 (LIMD1) on the sensitivity of lung adenocarcinoma cells to cisplatin and explore the mechanism.Methods: A549 and H1299 cells were transfected with lentivirus to establish LIMD1-overexpressing cell lines and their respective cont...

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Bibliographic Details
Main Authors: Xiaofei Zeng, Hong Wang, Dongsheng He, Weikun Jia, Ruidong Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Oncology
Subjects:
LIMD1
p38 MAPK
lung adenocarcinoma
cisplatin
apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00969/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00969/full

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