Effect of XlogP and hansen solubility parameters on the prediction of small molecule modified docetaxel, doxorubicin and irinotecan conjugates forming stable nanoparticles

Effect of XlogP and hansen solubility parameters on the prediction of small molecule modified docetaxel, doxorubicin and irinotecan conjugates forming stable nanoparticles

Small molecule-chemotherapeutic drug conjugate nanoparticles (SMCDC NPs) has a great advantage in improving drug loading. However, the factors which influence these conjugates forming stable nanoparticles (NPs) are currently unclear. In our previous studies, we synthesized a series of fatty acid-pac...

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Bibliographic Details
Main Authors: Mei-Qi Xu, Ting Zhong, Xin Yao, Zhuo-Yue Li, Hui Li, Jing-Ru Wang, Zhen-Han Feng, Xuan Zhang
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Drug Delivery
Subjects:
docetaxel
doxorubicin
irinotecan
hydrophobic parameters (xlogp)
solubility parameters
conjugate
nanoparticles
prediction
Online Access:http://dx.doi.org/10.1080/10717544.2021.1958107

Internet

http://dx.doi.org/10.1080/10717544.2021.1958107

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