Polystyrene nanoplastics induce apoptosis, autophagy, and steroidogenesis disruption in granulosa cells to reduce oocyte quality and fertility by inhibiting the PI3K/AKT pathway in female mice

Polystyrene nanoplastics induce apoptosis, autophagy, and steroidogenesis disruption in granulosa cells to reduce oocyte quality and fertility by inhibiting the PI3K/AKT pathway in female mice

Abstract Background Nanoplastics (NPs) are emerging pollutants that pose risks to living organisms. Recent findings have unveiled the reproductive harm caused by polystyrene nanoparticles (PS-NPs) in female animals, yet the intricate mechanism remains incompletely understood. Under this research, we...

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Bibliographic Details
Main Authors: Yue Xue, Xiu Cheng, Zhang-Qiang Ma, Hou-Peng Wang, Chong Zhou, Jia Li, Da-Lei Zhang, Liao-Liao Hu, Yan-Fan Cui, Jian Huang, Tao Luo, Li-Ping Zheng
Format: Article
Language:English
Published: BMC 2024-08-01
Series:Journal of Nanobiotechnology
Subjects:
Apoptosis
Autophagy
Oocyte quality
PI3K/AKT signaling pathway
Polystyrene nanoplastics
Online Access:https://doi.org/10.1186/s12951-024-02735-7

Internet

https://doi.org/10.1186/s12951-024-02735-7

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