“Dual Anta-Inhibitors” of the A<sub>2A</sub> Adenosine Receptor and Casein Kinase CK1delta: Synthesis, Biological Evaluation, and Molecular Modeling Studies

“Dual Anta-Inhibitors” of the A<sub>2A</sub> Adenosine Receptor and Casein Kinase CK1delta: Synthesis, Biological Evaluation, and Molecular Modeling Studies

Based on a screening of a chemical library of A<sub>2A</sub> adenosine receptor (AR) antagonists, a series of di- and tri-substituted adenine derivatives were synthesized and tested for their ability to inhibit the activity of the enzyme casein kinase 1 delta (CK1δ) and to bind adenosine...

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Bibliographic Details
Main Authors: Andrea Spinaci, Michela Buccioni, Daniela Catarzi, Chang Cui, Vittoria Colotta, Diego Dal Ben, Eleonora Cescon, Beatrice Francucci, Ilenia Grieco, Catia Lambertucci, Gabriella Marucci, Davide Bassani, Matteo Pavan, Flavia Varano, Stephanie Federico, Giampiero Spalluto, Stefano Moro, Rosaria Volpini
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Pharmaceuticals
Subjects:
“dual anta-inhibitors”
CK1δ inhibitors
A<sub>2A</sub> adenosine receptor antagonists
molecular modeling
computational study
Online Access:https://www.mdpi.com/1424-8247/16/2/167

Internet

https://www.mdpi.com/1424-8247/16/2/167

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