pSTAT3 transactivates EGFR in maintaining EGFR protein homeostasis and EGFR-TKI resistance

pSTAT3 transactivates EGFR in maintaining EGFR protein homeostasis and EGFR-TKI resistance

EGFR protein trafficking is critical for regulating multiple biological processes, including cell growth and survival. However, how EGFR protein homeostasis is maintained remains unclear. In this study, we show that a reduction in plasma membrane-associated EGFR triggers EGFR transcription by promot...

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Bibliographic Details
Main Authors: Ao Juan, Fei Junjie, Wang Guoqiang, Zhang Wenhua, Yu Shuhan, Guo Rongtian, Niu Mengmeng, Chen Hu, Cao Yang, Xiao Zhi-Xiong Jim, Yi Yong
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2024-09-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
EGFR
pSTAT3
protein homeostasis
EGFR-TKI resistance
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2024166

Internet

https://www.sciengine.com/doi/10.3724/abbs.2024166

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