Disrupting circadian homeostasis of sympathetic signaling promotes tumor development in mice.

Disrupting circadian homeostasis of sympathetic signaling promotes tumor development in mice.

Cell proliferation in all rapidly renewing mammalian tissues follows a circadian rhythm that is often disrupted in advanced-stage tumors. Epidemiologic studies have revealed a clear link between disruption of circadian rhythms and cancer development in humans. Mice lacking the circadian genes Period...

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Bibliographic Details
Main Authors: Susie Lee, Lawrence A Donehower, Alan J Herron, David D Moore, Loning Fu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2881876?pdf=render

Internet

http://europepmc.org/articles/PMC2881876?pdf=render

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