NINJ1 mediates inflammatory cell death, PANoptosis, and lethality during infection conditions and heat stress

NINJ1 mediates inflammatory cell death, PANoptosis, and lethality during infection conditions and heat stress

Abstract Innate immunity provides the first line of defense through multiple mechanisms, including pyrogen production and cell death. While elevated body temperature during infection is beneficial to clear pathogens, heat stress (HS) can lead to inflammation and pathology. Links between pathogen exp...

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Bibliographic Details
Main Authors: Joo-Hui Han, Rajendra Karki, R. K. Subbarao Malireddi, Raghvendra Mall, Roman Sarkar, Bhesh Raj Sharma, Jonathon Klein, Harmut Berns, Harshan Pisharath, Shondra M. Pruett-Miller, Sung-Jin Bae, Thirumala-Devi Kanneganti
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-45466-x

Internet

https://doi.org/10.1038/s41467-024-45466-x

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