A Novel Derivative of Curcumol, HCL-23, Inhibits the Malignant Phenotype of Triple-Negative Breast Cancer and Induces Apoptosis and HO-1-Dependent Ferroptosis

A Novel Derivative of Curcumol, HCL-23, Inhibits the Malignant Phenotype of Triple-Negative Breast Cancer and Induces Apoptosis and HO-1-Dependent Ferroptosis

Triple-negative breast cancer (TNBC) is the most aggressive molecular subtype of breast cancer. Curcumol, as a natural small molecule compound, has potential anti-breast cancer activity. In this study, we chemically synthesized a derivative of curcumol, named HCL-23, by structural modification and e...

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Bibliographic Details
Main Authors: Peng Zhao, Hui Song, Futian Gao, Liang Chen, Jianfei Qiu, Jun Jin, Chaolan Pan, Yunyan Tang, Meijun Chen, Yang Pan, Yanmei Li, Liejun Huang, Jue Yang, Xiaojiang Hao
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Molecules
Subjects:
triple-negative breast cancer
curcumol derivative
metastasis
apoptosis
ferroptosis
Online Access:https://www.mdpi.com/1420-3049/28/8/3389

Internet

https://www.mdpi.com/1420-3049/28/8/3389

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