A Blockade of IGF Signaling Sensitizes Human Ovarian Cancer Cells to the Anthelmintic Niclosamide-Induced Anti-Proliferative and Anticancer Activities

A Blockade of IGF Signaling Sensitizes Human Ovarian Cancer Cells to the Anthelmintic Niclosamide-Induced Anti-Proliferative and Anticancer Activities

Background/Aims: Ovarian cancer is the most lethal gynecologic malignancy, and there is an unmet clinical need to develop new therapies. Although showing promising anticancer activity, Niclosamide may not be used as a monotherapy. We seek to investigate whether inhibiting IGF signaling potentiates N...

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Bibliographic Details
Main Authors: Youlin Deng, Zhongliang Wang, Fugui Zhang, Min Qiao, Zhengjian Yan, Qiang Wei, Jing Wang, Hao Liu, Jiaming Fan, Yulong Zou, Junyi Liao, Xue Hu, Liqun Chen, Xinyi Yu, Rex C. Haydon, Hue H. Luu, Hongbo Qi, Tong-Chuan He, Junhui Zhang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-08-01
Series:Cellular Physiology and Biochemistry
Subjects:
Cancer pathways
Cell signaling
Synergistic effect
Cancer therapy
IGF signaling
IGF-1R
Ovarian cancer
Drug repurposing
Niclosamide
Online Access:http://prod.karger.com/Article/FullText/447797

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http://prod.karger.com/Article/FullText/447797

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