Amino-3,5-Dicyanopyridines Targeting the Adenosine Receptors. Ranging from Pan Ligands to Combined A1/A2B Partial Agonists

Amino-3,5-Dicyanopyridines Targeting the Adenosine Receptors. Ranging from Pan Ligands to Combined A1/A2B Partial Agonists

The amino-3,5-dicyanopyridine derivatives belong to an intriguing series of adenosine receptor (AR) ligands that has been developed by both academic researchers and industry. Indeed, the studies carried out to date underline the versatility of the dicyanopyridine scaffold to obtain AR ligands with n...

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Bibliographic Details
Main Authors: Daniela Catarzi, Flavia Varano, Katia Varani, Fabrizio Vincenzi, Silvia Pasquini, Diego Dal Ben, Rosaria Volpini, Vittoria Colotta
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Pharmaceuticals
Subjects:
g protein-coupled receptors
adenosine a<sub>2b</sub> receptor ligands
adenosine a<sub>1</sub> receptor ligands
aminopyridine-3,5-dicarbonitriles
ligand-adenosine receptor modeling studies
Online Access:https://www.mdpi.com/1424-8247/12/4/159

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https://www.mdpi.com/1424-8247/12/4/159

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