Innate and Adaptive Responses of Intratumoral Immunotherapy with Endosomal Toll-Like Receptor Agonists

Innate and Adaptive Responses of Intratumoral Immunotherapy with Endosomal Toll-Like Receptor Agonists

Toll-like receptors (TLRs) are natural initial triggers of innate and adaptive immune responses. With the advent of cancer immunotherapy, nucleic acids engineered as ligands of endosomal TLRs have been investigated for the treatment of solid tumors. Despite promising results, their systemic administ...

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Bibliographic Details
Main Authors: Fernando Torres Andón, Sergio Leon, Aldo Ummarino, Esther Redin, Paola Allavena, Diego Serrano, Clément Anfray, Alfonso Calvo
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Biomedicines
Subjects:
toll-like receptors
TLR agonists
intratumoral administration
antitumoral immunotherapy
tumor associated macrophages
Online Access:https://www.mdpi.com/2227-9059/10/7/1590

Internet

https://www.mdpi.com/2227-9059/10/7/1590

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