Sestrin2 induced by hypoxia inducible factor1 alpha protects the blood-brain barrier via inhibiting VEGF after severe hypoxic-ischemic injury in neonatal rats

Sestrin2 induced by hypoxia inducible factor1 alpha protects the blood-brain barrier via inhibiting VEGF after severe hypoxic-ischemic injury in neonatal rats

Objective: Hypoxic ischemic (HI) encephalopathy remains the leading cause of perinatal brain injury resulting in long term disabilities. Stabilization of blood brain barrier (BBB) after HI is an important target, therefore, in this study we aim to determine the role of sestrin2, a stress inducible p...

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Bibliographic Details
Main Authors: Xudan Shi, Desislava Met Doycheva, Liang Xu, Jiping Tang, Min Yan, John H. Zhang
Format: Article
Language:English
Published: Elsevier 2016-11-01
Series:Neurobiology of Disease
Subjects:
Hi 95
Hypoxia inducible factor1
Brain edema
Neonatal hypoxic-ischemic encephalopathy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116301759

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http://www.sciencedirect.com/science/article/pii/S0969996116301759

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