The Progressive Mutagenic Effects of Acidic Bile Refluxate in Hypopharyngeal Squamous Cell Carcinogenesis: New Insights

The Progressive Mutagenic Effects of Acidic Bile Refluxate in Hypopharyngeal Squamous Cell Carcinogenesis: New Insights

Cancers of the laryngopharynx represent the most devastating of the head and neck malignancies and additional risk factors are now epidemiologically linked to this disease. Using an in vivo model (<i>Mus musculus</i> C57Bl/6J), we provide novel evidence that acidic bile (pH 3.0) progress...

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Bibliographic Details
Main Authors: Clarence T. Sasaki, Sotirios G. Doukas, Jose Costa, Dimitra P. Vageli
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cancers
Subjects:
bile reflux
NF-<i>κ</i>B
DNA damage
hypopharyngeal cancer
head and neck cancer
Online Access:https://www.mdpi.com/2072-6694/12/5/1064

Internet

https://www.mdpi.com/2072-6694/12/5/1064

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