New Multi-Targeted Antiproliferative Agents: Design and Synthesis of IC261-Based Oxindoles as Potential Tubulin, CK1 and EGFR Inhibitors

New Multi-Targeted Antiproliferative Agents: Design and Synthesis of IC261-Based Oxindoles as Potential Tubulin, CK1 and EGFR Inhibitors

A series of 3-benzylideneindolin-2-one compounds was designed and synthesized based on combretastatin A-4 and compound <b>IC261</b>, a dual casein kinase (CK1)/tubulin polymerization inhibitor, taking into consideration the pharmacophore required for EGFR-tyrosine kinase inhibition. The...

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Bibliographic Details
Main Authors: Momen R. Fareed, Mai E. Shoman, Mohammed I. A. Hamed, Mohamed Badr, Hanin A. Bogari, Sameh S. Elhady, Tarek S. Ibrahim, Gamal El-Din A. Abuo-Rahma, Taha F. S. Ali
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Pharmaceuticals
Subjects:
oindoles
antiproliferative
tubulin polymerization inhibitors
EGFR kinase inhibitors
casein kinase
Online Access:https://www.mdpi.com/1424-8247/14/11/1114

Internet

https://www.mdpi.com/1424-8247/14/11/1114

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