BDNF is altered in a brain-region specific manner and rescues deficits in Spinocerebellar Ataxia Type 1

BDNF is altered in a brain-region specific manner and rescues deficits in Spinocerebellar Ataxia Type 1

Spinocerebellar ataxia type 1 (SCA1) is an adult-onset, dominantly inherited neurodegenerative disease caused by the expanded polyQ tract in the protein ATAXIN1 (ATXN1) and characterized by progressive motor and cognitive impairments. There are no disease-modifying treatments or cures for SCA1. Brai...

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Bibliographic Details
Main Authors: Juao-Guilherme Rosa, Katherine Hamel, Alyssa Soles, Carrie Sheeler, Ella Borgenheimer, Stephen Gilliat, Kaelin Sbrocco, Ferris Ghanoum, Hillary P. Handler, Colleen Forster, Orion Rainwater, Marija Cvetanovic
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Neurobiology of Disease
Subjects:
SCA1
BDNF
Neurodegeneration
Brain region specific
Motor deficits
Cognition
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123000372

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http://www.sciencedirect.com/science/article/pii/S0969996123000372

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