Predicting T Cell Receptor Antigen Specificity From Structural Features Derived From Homology Models of Receptor-Peptide-Major Histocompatibility Complexes

Predicting T Cell Receptor Antigen Specificity From Structural Features Derived From Homology Models of Receptor-Peptide-Major Histocompatibility Complexes

The physical interaction between the T cell receptor (TCR) and its cognate antigen causes T cells to activate and participate in the immune response. Understanding this physical interaction is important in predicting TCR binding to a target epitope, as well as potential cross-reactivity. Here, we pr...

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Bibliographic Details
Main Authors: Martina Milighetti, John Shawe-Taylor, Benny Chain
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Physiology
Subjects:
T cell receptor
antigen prediction
TCR-pMHC binding
homology modelling
T cell
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.730908/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.730908/full

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