Heterogeneity of Phenotype and Function Reflects the Multistage Development of T Follicular Helper Cells

Heterogeneity of Phenotype and Function Reflects the Multistage Development of T Follicular Helper Cells

T follicular helper cells (Tfh) provide crucial signals for germinal center (GC) formation, but Tfh populations are heterogeneous. While PD1hi Tfh are important in the GC response, the function of the PD1lo Tfh-like subset is unknown. We show that these cells, like the PD1hi GC–Tfh, depend upon B ce...

Täydet tiedot

Bibliografiset tiedot
Päätekijät: David Gray, Marta Trüb, Tom A. Barr, Vicky L. Morrison, Sheila Brown, Stefano Caserta, Jordan Rixon, Alasdair Ivens
Aineistotyyppi: Artikkeli
Kieli:English
Julkaistu: Frontiers Media S.A. 2017-04-01
Sarja:Frontiers in Immunology
Aiheet:
T follicular helper cells
T cell memory
T follicular helper cell subsets
germinal centres
T cell heterogeneity
Linkit:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00489/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00489/full

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