Heterogeneity of Phenotype and Function Reflects the Multistage Development of T Follicular Helper Cells

Heterogeneity of Phenotype and Function Reflects the Multistage Development of T Follicular Helper Cells

T follicular helper cells (Tfh) provide crucial signals for germinal center (GC) formation, but Tfh populations are heterogeneous. While PD1hi Tfh are important in the GC response, the function of the PD1lo Tfh-like subset is unknown. We show that these cells, like the PD1hi GC–Tfh, depend upon B ce...

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Bibliographic Details
Main Authors: David Gray, Marta Trüb, Tom A. Barr, Vicky L. Morrison, Sheila Brown, Stefano Caserta, Jordan Rixon, Alasdair Ivens
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-04-01
Series:Frontiers in Immunology
Subjects:
T follicular helper cells
T cell memory
T follicular helper cell subsets
germinal centres
T cell heterogeneity
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00489/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00489/full

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