NlpC/P60 peptidoglycan hydrolases of Trichomonas vaginalis have complementary activities that empower the protozoan to control host-protective lactobacilli.

Trichomonas vaginalis is a human protozoan parasite that causes trichomoniasis, a prevalent sexually transmitted infection. Trichomoniasis is accompanied by a shift to a dysbiotic vaginal microbiome that is depleted of lactobacilli. Studies on co-cultures have shown that vaginal bacteria in eubiosis...

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Bibliographic Details
Main Authors: Michael J Barnett, Jully Pinheiro, Jeremy R Keown, Jacob Biboy, Joe Gray, Ioana-Wilhelmina Lucinescu, Waldemar Vollmer, Robert P Hirt, Augusto Simoes-Barbosa, David C Goldstone
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-08-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1011563