18-α-glycyrrhetinic acid alleviates oxidative damage in periodontal tissue by modulating the interaction of Cx43 and JNK/NF-κB pathways

18-α-glycyrrhetinic acid alleviates oxidative damage in periodontal tissue by modulating the interaction of Cx43 and JNK/NF-κB pathways

Objective: Periodontitis is a common chronic inflammatory disease in which oxidative stress is one of the key pathogenic factors. Connexin43 (Cx43) is the most critical and widely distributed connexin isoform. When the organism undergoes a severe and sustained stress response, Cx43-mediated gap junc...

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Bibliographic Details
Main Authors: Niuben Cao, Xiaomeng Liu, Yubo Hou, Yu Deng, Yu Xin, Xirui Xin, Xinchen Xiang, Xinchan Liu, Weixian Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Pharmacology
Subjects:
periodontitis
18-α-glycyrrhetinic acid
oxidative stress
apoptosis
gap junctions
connexin43
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1221053/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1221053/full

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