Potential TMA-Producing Bacteria Are Ubiquitously Found in Mammalia

Human gut bacteria metabolize dietary components such as choline and carnitine to trimethylamine (TMA) that is subsequently oxidized to trimethylamine-N-oxide (TMAO) by hepatic enzymes. Increased plasma levels of TMAO are associated with the development of cardiovascular and renal disease. In this s...

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Bibliographic Details
Main Authors: Silke Rath, Tatjana Rud, Dietmar H. Pieper, Marius Vital
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Microbiology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.02966/full