Validation of the C-X-C chemokine receptor 3 (CXCR3) as a target for PET imaging of T cell activation

Validation of the C-X-C chemokine receptor 3 (CXCR3) as a target for PET imaging of T cell activation

Abstract Purpose CXCR3 is expressed on activated T cells and plays a crucial role in T-cell recruitment to the tumor microenvironment (TME) during cell-based and immune checkpoint inhibitor (ICI) immunotherapy. This study utilized a 64Cu-labeled NOTA-α-CXCR3 antibody to assess CXCR3 expression in th...

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Bibliographic Details
Main Authors: Sebastian Martin, Lennard Wendlinger, Béatrice Zitti, Mehdi Hicham, Viktoriia Postupalenko, Léo Marx, Greta Giordano-Attianese, Elisabetta Cribioli, Melita Irving, Alexandra Litvinenko, Radmila Faizova, David Viertl, Margret Schottelius
Format: Article
Language:English
Published: SpringerOpen 2024-08-01
Series:EJNMMI Research
Subjects:
CXCR3
Immunotherapy
Chemokine receptor
T cell activation imaging
Online Access:https://doi.org/10.1186/s13550-024-01142-1

Internet

https://doi.org/10.1186/s13550-024-01142-1

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