Phosphoproteomics reveals that cinobufotalin promotes intrahepatic cholangiocarcinoma cell apoptosis by activating the ATM/CHK2/p53 signaling pathway

Phosphoproteomics reveals that cinobufotalin promotes intrahepatic cholangiocarcinoma cell apoptosis by activating the ATM/CHK2/p53 signaling pathway

Intrahepatic cholangiocarcinoma (ICC) is a malignant tumor that originates from bile duct’s epithelial cells and is usually characterized by insidious symptoms and poor prognosis. Cinobufotalin (CB), an active ingredient obtained from the Traditional Chinese Medicine ChanSu, is purported to exhibit...

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Bibliographic Details
Main Authors: Zhili Xia, Minzhen Li, Meng Hu, Yanyan Lin, Lawrence Lawer Atteh, Wenkang Fu, Long Gao, Mingzhen Bai, Chongfei Huang, Ping Yue, Yu Liu, Wenbo Meng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Oncology
Subjects:
cinobufotalin
phosphoproteome
intrahepatic cholangiocarcinoma
DNA damage
apoptosis
ATM/CHK2/p53 signaling pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.982961/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.982961/full

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