BBD Driven Fabrication of Hydroxyapatite Engineered Risedronate Loaded Thiolated Chitosan Nanoparticles and Their In Silico, In Vitro, and Ex Vivo Studies

BBD Driven Fabrication of Hydroxyapatite Engineered Risedronate Loaded Thiolated Chitosan Nanoparticles and Their In Silico, In Vitro, and Ex Vivo Studies

Risedronate sodium (RIS) exhibits limited bioavailability and undesirable gastrointestinal effects when administered orally, necessitating the development of an alternative formulation. In this study, mPEG-coated nanoparticles loaded with RIS-HA-TCS were created for osteoporosis treatment. Thiolated...

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Bibliographic Details
Main Authors: Zoya Saifi, Tanya Ralli, Md. Rizwanullah, Meraj Alam, Divya Vohora, Showkat R. Mir, Saima Amin, Sadia Ameen
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Micromachines
Subjects:
risedronate
thiolated chitosan
PEGylated nanoparticles
osteoporosis
hydroxyapatite
Online Access:https://www.mdpi.com/2072-666X/14/12/2182

Internet

https://www.mdpi.com/2072-666X/14/12/2182

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