Heterocellular N-cadherin junctions enable nontransformed cells to inhibit the growth of adjacent transformed cells

Heterocellular N-cadherin junctions enable nontransformed cells to inhibit the growth of adjacent transformed cells

Abstract Background The Src tyrosine kinase phosphorylates effector proteins to induce expression of the podoplanin (PDPN) receptor in order to promote tumor progression. However, nontransformed cells can normalize the growth and morphology of neighboring transformed cells. Transformed cells must es...

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Bibliographic Details
Main Authors: Stephanie A. Sheehan, Edward P. Retzbach, Yongquan Shen, Harini Krishnan, Gary S. Goldberg
Format: Article
Language:English
Published: BMC 2022-02-01
Series:Cell Communication and Signaling
Subjects:
Cadherins
Cancer
Cell junctions
Contact normalization
Oral squamous cell carcinoma
Podoplanin
Online Access:https://doi.org/10.1186/s12964-021-00817-9

Internet

https://doi.org/10.1186/s12964-021-00817-9

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