Lactate-modulated induction of THBS-1 activates transforming growth factor (TGF)-beta2 and migration of glioma cells in vitro.

Lactate-modulated induction of THBS-1 activates transforming growth factor (TGF)-beta2 and migration of glioma cells in vitro.

<h4>Background</h4>An important phenomenon observed in glioma metabolism is increased aerobic glycolysis in tumor cells, which is generally referred to as the Warburg effect. Transforming growth factor (TGF)-beta2, which we previously showed to be induced by lactic acid, is a key pathoph...

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Main Authors: Corinna Seliger, Petra Leukel, Sylvia Moeckel, Birgit Jachnik, Claudio Lottaz, Marina Kreutz, Alexander Brawanski, Martin Proescholdt, Ulrich Bogdahn, Anja-Katrin Bosserhoff, Arabel Vollmann-Zwerenz, Peter Hau
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24223867/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24223867/pdf/?tool=EBI

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