Paired protein kinases PRKCI-RIPK2 promote pancreatic cancer growth and metastasis via enhancing NF-κB/JNK/ERK phosphorylation

Paired protein kinases PRKCI-RIPK2 promote pancreatic cancer growth and metastasis via enhancing NF-κB/JNK/ERK phosphorylation

Abstract Background Protein kinases play a pivotal role in the malignant evolution of pancreatic cancer (PC) through mediating phosphorylation. Many kinase inhibitors have been developed and translated into clinical use, while the complex pathology of PC confounds their clinical efficacy and warrant...

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Bibliographic Details
Main Authors: Juying Jiao, Linjie Ruan, Chien-shan Cheng, Fengjiao Wang, Peiwen Yang, Zhen Chen
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Molecular Medicine
Subjects:
Pancreatic cancer
Protein kinase
Receptor interacting protein kinase 2
Protein kinase C iota
Phosphorylation
Online Access:https://doi.org/10.1186/s10020-023-00648-z

Internet

https://doi.org/10.1186/s10020-023-00648-z

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