Quantification of variation and the impact of biomass in targeted 16S rRNA gene sequencing studies

Quantification of variation and the impact of biomass in targeted 16S rRNA gene sequencing studies

Abstract Background Recent advances in sequencing technologies and bioinformatics tools have allowed for large-scale microbiome studies that are rapidly advancing medical research. However, small changes in technique or analysis can significantly alter the results and lead to conflicting findings. Q...

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Bibliographic Details
Main Authors: Jeffrey M. Bender, Fan Li, Helty Adisetiyo, David Lee, Sara Zabih, Long Hung, Thomas A. Wilkinson, Pia S. Pannaraj, Rosemary C. She, Jennifer Dien Bard, Nicole H. Tobin, Grace M. Aldrovandi
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Microbiome
Subjects:
Biomass
Technical variation
Biological variation
Precision
Accuracy
Online Access:http://link.springer.com/article/10.1186/s40168-018-0543-z

Internet

http://link.springer.com/article/10.1186/s40168-018-0543-z

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