Extracellular mycobacterial DnaK polarizes macrophages to the M2-like phenotype.

Extracellular mycobacterial DnaK polarizes macrophages to the M2-like phenotype.

Macrophages are myeloid cells that play an essential role in inflammation and host defense, regulating immune responses and maintaining tissue homeostasis. Depending on the microenvironment, macrophages can polarize to two distinct phenotypes. The M1 phenotype is activated by IFN-γ and bacterial pro...

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Bibliographic Details
Main Authors: Rafael L Lopes, Thiago J Borges, Jessica F Araújo, Nathana G Pinho, Letícia S Bergamin, Ana Maria O Battastini, Stéfanie P Muraro, Ana Paula D Souza, Rafael F Zanin, Cristina Bonorino
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4242626?pdf=render

Internet

http://europepmc.org/articles/PMC4242626?pdf=render

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