A Matrine Derivative M54 Suppresses Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss by Targeting Ribosomal Protein S5

A Matrine Derivative M54 Suppresses Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss by Targeting Ribosomal Protein S5

Post-menopausal osteoporosis (PMOP) is a metabolic bone disorder characterized by low bone mass and micro-architectural deterioration of bone tissue. The over-activated osteoclastogenesis, which plays an important role in osteoporosis, has become an important therapeutic target. M54 was a bioactive...

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Bibliographic Details
Main Authors: Zhi Xin, Cui Jin, Liu Chao, Zhang Zheng, Cao Liehu, Pan Panpan, Weng Weizong, Zhai Xiao, Zhao Qingjie, Hu Honggang, Qin Longjuan, Chen Xiao, Su Jiacan
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Pharmacology
Subjects:
RPS5
matrine derivative
RANKL
osteoclasts
AKT pathway
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00022/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00022/full

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