Modeling the innate inflammatory cGAS/STING pathway: sexually dimorphic effects on microglia and cognition in obesity and prediabetes

Modeling the innate inflammatory cGAS/STING pathway: sexually dimorphic effects on microglia and cognition in obesity and prediabetes

IntroductionThe prevalence of obesity, prediabetes, and diabetes continues to grow worldwide. These metabolic dysfunctions predispose individuals to neurodegenerative diseases and cognitive impairment, including dementias such as Alzheimer’s disease and Alzheimer’s disease related dementias (AD/ADRD...

Full description

Bibliographic Details
Main Authors: Sarah E. Elzinga, Emily J. Koubek, John M. Hayes, A. Carter, Faye E. Mendelson, Ian Webber-Davis, Stephen I. Lentz, Eva L. Feldman
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
cGAS/STING pathway
cognitive impairment
high-fat diet (HFD)
obesity
inflammation
microglia
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2023.1167688/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2023.1167688/full

Similar Items