Atypical UV Photoproducts Induce Non-canonical Mutation Classes Associated with Driver Mutations in Melanoma

Atypical UV Photoproducts Induce Non-canonical Mutation Classes Associated with Driver Mutations in Melanoma

Summary: Somatic mutations in skin cancers and other ultraviolet (UV)-exposed cells are typified by C>T and CC>TT substitutions at dipyrimidine sequences; however, many oncogenic “driver” mutations in melanoma do not fit this UV signature. Here, we use genome sequencing to characterize mutatio...

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Bibliographic Details
Main Authors: Marian F. Laughery, Alexander J. Brown, Kaitlynne A. Bohm, Smitha Sivapragasam, Haley S. Morris, Mila Tchmola, Angelica D. Washington, Debra Mitchell, Stephen Mather, Ewa P. Malc, Piotr A. Mieczkowski, Steven A. Roberts, John J. Wyrick
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Cell Reports
Subjects:
UV damage
UV mutagenesis
skin cancer
thymine-adenine photoproduct
transcriptional asymmetry
BRAF
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720313905

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http://www.sciencedirect.com/science/article/pii/S2211124720313905

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