Synthesis and anti-prion aggregation activity of acylthiosemicarbazide analogues

Synthesis and anti-prion aggregation activity of acylthiosemicarbazide analogues

AbstractPrions are infectious protein particles known to cause prion diseases. The biochemical entity of the pathogen is the misfolded prion protein (PrPSc) that forms insoluble amyloids to impair brain function. PrPSc interacts with the non-pathogenic, cellular prion protein (PrPC) and facilitates...

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Bibliographic Details
Main Authors: Dong Hwan Kim, Jaehyeon Kim, Hakmin Lee, Dongyun Lee, So Myoung Im, Ye Eun Kim, Miryeong Yoo, Yong-Pil Cheon, Jason C. Bartz, Young-Jin Son, Eun-Kyoung Choi, Yong-Sun Kim, Jae-Ho Jeon, Hyo Shin Kim, Sungeun Lee, Chongsuk Ryou, Tae-gyu Nam
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Prion disease Creutzfeldt–Jakob disease
prion aggregation formation assay
acylthiosemicarbazide
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2023.2191164

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https://www.tandfonline.com/doi/10.1080/14756366.2023.2191164

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