Yeast proteinopathy models: a robust tool for deciphering the basis of neurodegeneration
Protein quality control or proteostasis is an essential determinant of basic cell health and aging. Eukaryotic cells have evolved a number of proteostatic mechanisms to ensure that proteins retain functional conformation, or are rapidly degraded when proteins misfold or self-aggregate. Disruption of...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Shared Science Publishers OG
2015-11-01
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| Series: | Microbial Cell |
| Subjects: | |
| Online Access: | http://microbialcell.com/researcharticles/yeast-proteinopathy-models-a-robust-tool-for-deciphering-the-basis-of-neurodegeneration/ |
| _version_ | 1819074489389940736 |
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| author | Amit Shrestha Lynn A. Megeney |
| author_facet | Amit Shrestha Lynn A. Megeney |
| author_sort | Amit Shrestha |
| collection | DOAJ |
| description | Protein quality control or proteostasis is an essential determinant of basic cell health and aging. Eukaryotic cells have evolved a number of proteostatic mechanisms to ensure that proteins retain functional conformation, or are rapidly degraded when proteins misfold or self-aggregate. Disruption of proteostasis is now widely recognized as a key feature of aging related illness, specifically neurodegenerative disease. For example, Alzheimer’s disease, Huntington’s disease, Parkinson’s disease and Amyotrophic Lateral Sclerosis (ALS) each target and afflict distinct neuronal cell subtypes, yet this diverse array of human pathologies share the defining feature of aberrant protein aggregation within the affected cell population. Here, we review the use of budding yeast as a robust proxy to study the intersection between proteostasis and neurodegenerative disease. The humanized yeast model has proven to be an amenable platform to identify both, conserved proteostatic mechanisms across eukaryotic phyla and novel disease specific molecular dysfunction. Moreover, we discuss the intriguing concept that yeast specific proteins may be utilized as bona fide therapeutic agents, to correct proteostasis errors across various forms of neurodegeneration. |
| first_indexed | 2024-12-21T18:10:20Z |
| format | Article |
| id | doaj.art-1ff270bb874a424b86005beb1fb61158 |
| institution | Directory Open Access Journal |
| issn | 2311-2638 |
| language | English |
| last_indexed | 2024-12-21T18:10:20Z |
| publishDate | 2015-11-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Microbial Cell |
| spelling | doaj.art-1ff270bb874a424b86005beb1fb611582022-12-21T18:54:49ZengShared Science Publishers OGMicrobial Cell2311-26382015-11-0121245846510.15698/mic2015.12.243Yeast proteinopathy models: a robust tool for deciphering the basis of neurodegenerationAmit Shrestha0Lynn A. Megeney1Ottawa Hospital Research Institute, Regenerative Medicine Program, Sprott Centre for Stem Cell Research, The Ottawa Hospital, Ottawa, Ontario, Canada.Ottawa Hospital Research Institute, Regenerative Medicine Program, Sprott Centre for Stem Cell Research, The Ottawa Hospital, Ottawa, Ontario, Canada.Protein quality control or proteostasis is an essential determinant of basic cell health and aging. Eukaryotic cells have evolved a number of proteostatic mechanisms to ensure that proteins retain functional conformation, or are rapidly degraded when proteins misfold or self-aggregate. Disruption of proteostasis is now widely recognized as a key feature of aging related illness, specifically neurodegenerative disease. For example, Alzheimer’s disease, Huntington’s disease, Parkinson’s disease and Amyotrophic Lateral Sclerosis (ALS) each target and afflict distinct neuronal cell subtypes, yet this diverse array of human pathologies share the defining feature of aberrant protein aggregation within the affected cell population. Here, we review the use of budding yeast as a robust proxy to study the intersection between proteostasis and neurodegenerative disease. The humanized yeast model has proven to be an amenable platform to identify both, conserved proteostatic mechanisms across eukaryotic phyla and novel disease specific molecular dysfunction. Moreover, we discuss the intriguing concept that yeast specific proteins may be utilized as bona fide therapeutic agents, to correct proteostasis errors across various forms of neurodegeneration.http://microbialcell.com/researcharticles/yeast-proteinopathy-models-a-robust-tool-for-deciphering-the-basis-of-neurodegeneration/yeastneurodegenerationproteinopathyHsp104Yca1TDP-43α-synuclein |
| spellingShingle | Amit Shrestha Lynn A. Megeney Yeast proteinopathy models: a robust tool for deciphering the basis of neurodegeneration Microbial Cell yeast neurodegeneration proteinopathy Hsp104 Yca1 TDP-43 α-synuclein |
| title | Yeast proteinopathy models: a robust tool for deciphering the basis of neurodegeneration |
| title_full | Yeast proteinopathy models: a robust tool for deciphering the basis of neurodegeneration |
| title_fullStr | Yeast proteinopathy models: a robust tool for deciphering the basis of neurodegeneration |
| title_full_unstemmed | Yeast proteinopathy models: a robust tool for deciphering the basis of neurodegeneration |
| title_short | Yeast proteinopathy models: a robust tool for deciphering the basis of neurodegeneration |
| title_sort | yeast proteinopathy models a robust tool for deciphering the basis of neurodegeneration |
| topic | yeast neurodegeneration proteinopathy Hsp104 Yca1 TDP-43 α-synuclein |
| url | http://microbialcell.com/researcharticles/yeast-proteinopathy-models-a-robust-tool-for-deciphering-the-basis-of-neurodegeneration/ |
| work_keys_str_mv | AT amitshrestha yeastproteinopathymodelsarobusttoolfordecipheringthebasisofneurodegeneration AT lynnamegeney yeastproteinopathymodelsarobusttoolfordecipheringthebasisofneurodegeneration |